Free Webinar: Development of Automated Chemometric Platform for Accelerated Raman-based Model Optimization in Biologics

BioPharma-Asia webinar registrationBrian Rohrback, president of Infometrix, will join Oliver Steinhof, PAT Scientist at Biogen and Nicolas Langenegger, Senior Associate Scientist at Biogen for this free webinar on September 20, 2021 at 10:00am EST.

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The increasing use of multivariate models both as part of the control strategy in commercial (bio)pharmaceutical production as well as for process monitoring calls for an efficient strategy for model development and model life cycle management. The traditional approach to develop multivariate models based on spectroscopy involves manual data management such as selection and transfer of spectroscopic data, import into modeling software and selection/exclusion of data. That is followed by addition of reference data, alignment of time stamps and import into the modeling software. 90% of the time required to construct a multivariate model is spent on data preparation. It was decided to develop a solution to automate these steps to prepare (stage) the data required for model development, reducing the time required to prepare a typical set of batch data to about five minutes. A second tool was developed to automatically optimize data pretreatment parameters and spectral range for PLS models. Both tools allow our scientists to invest their time into more value-added activities.

APACT’21 On-line Conference: Industrial Strength Analytics

Join Brian Rohrback, president of Infometrix, for his talk on Industrial Strength Analytics Friday April 23rd at 13:00 BST.

The conference is free to attend and is open to all. Register at:

Industrial Strength Analytics

As scientists, we need to be focused on specific aspects of technology in order to make advances in our fields. Success in the lab is key, but if we want to reap the benefits, the tasks that come next are every bit as critical as the initial innovation. In order for the work to be useful in the manufacturing sector, the analytics need to be industrialized and often the peripheral portions of this hardening process are as complex as the discovery process and it takes time, often more than Phase I. The example here is to outline the steps required to optimize the use of optical spectroscopy in manufacturing quality control.

ISA Webinar – Practical AI: In Search of Dynamic, Autonomous Process Analytics

ISA 2021 webinar postingJoin Brian Rohrback, President of Infometrix on Feb. 25th at 1:00pm ET.

Free Webinar: Process Control & Instrumentation Series



Practical AI: In Search of Dynamic, Autonomous Process Analytics

The application of the concepts behind artificial intelligence and machine learning mandates a systematic approach to extracting information from multiple, byte-dense data sources. Effective extraction of this information leads to improvements in decision making at all levels of the chemical, petrochemical, and petroleum industries. To accomplish anything in the AI space, we need to combine traditional approaches in statistics, database organization, pattern recognition, and chemometrics with some newer concepts tied to better understanding of data mining, neurocomputing, and machine learning. This is an introduction to a practical approach to deploying AI and how a multi-company, multi-industry, hydrocarbon processing consortium, established eight years ago to re-evaluate how the calibration process for sensors and analyzers could be managed more efficiently. The focus spans optical spectrometers, chromatographs, and process sensors, independently and in combination, with a shift from current practices to approaches that take advantage of the computational power at our fingertips.

Dr. Rohrback’s expertise covers the integration of multivariate data processing for process analyzers and laboratory instruments catering to routine quality analysis. Prior to his current position, he worked for Cities Services Oil Company, now Occidental Petroleum, with industry positions including research scientist managing the chromatography group, an exploration geologist, and manager of planning/budget for EAME. He holds a B.S. in chemistry, a Ph.D. in organic geochemistry, and an MBA. His 50-year span of published works include topics in petroleum exploration, chemical plant optimization, clinical and pharmaceutical diagnostics, informatics, pattern recognition and multivariate analysis.