In this post, we outline the integration of retention time alignment such that the correction of chromatographic peak position can be done as part of a method. The technical underpinnings of the algorithm in LineUp come from the literature describing Correlation Optimized Warping, or COW, which was brought into active research by the Danish Technical University a decade ago.  But, having an algorithm and using it as part of a routine process in a lab or on-line are very different topics; we focus here on the effective integration of alignment into a chromatographic instrument method. Continue reading →